Communication

Stimulation of Neural Cells by Lateral Currents in Conductive Layer-by-Layer Films of Single-Walled Carbon Nanotubes†

  1. M. K. Gheith2,4,
  2. T. C. Pappas3,
  3. A. V. Liopo3,
  4. V. A. Sinani1,
  5. B. S. Shim1,
  6. M. Motamedi3,
  7. J. P. Wicksted2,
  8. N. A. Kotov1

Article first published online: 14 NOV 2006

DOI: 10.1002/adma.200600878

Issue

Advanced Materials

Advanced Materials

Volume 18, Issue 22, pages 2975–2979, November, 2006

Additional Information

How to Cite

Gheith, M., Pappas, T., Liopo, A., Sinani, V., Shim, B., Motamedi, M., Wicksted, J. and Kotov, N. (2006), Stimulation of Neural Cells by Lateral Currents in Conductive Layer-by-Layer Films of Single-Walled Carbon Nanotubes. Advanced Materials, 18: 2975–2979. doi: 10.1002/adma.200600878

Author Information

  1. 1

    Department of Chemical Engineering, Department of Biomedical Engineering, Department of Materials Science, University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109-2136, USA

  2. 2

    Department of Physics, Oklahoma State University, 145 Physical Sciences Building, Stillwater, OK 74078-3072, USA

  3. 3

    Center for Biomedical Engineering, University of Texas Medical Branch, Jennie Sealy Hospital, Galveston, TX 77555-0144, USA

  4. 4

    Present address: Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA

  1. †

    The authors thank the funding agencies including NSF BioPhotonics (BES-0119483 NAK, BES 0119544 MM), NSF CAREER award CHE-9876265 NAK) and NSF EPSCoR grant EPS-0132534. The authors thank Prof. Alexander A. Yaroslavov (M. V. Lomonosov Moscow State University) for his kind supply of the amphiphilic polymer used in the study. MKG and NAK thank Ms. Phoebi Doss for her assistance with SEM samples preparation.

Publication History

  1. Issue published online: 14 NOV 2006
  2. Article first published online: 14 NOV 2006
  3. Manuscript Revised: 15 AUG 2006
  4. Manuscript Received: 22 APR 2006

Funded by

  • NSF BioPhotonics. Grant Numbers: BES-0119483 NAK, BES 0119544 MM
  • NSF CAREER. Grant Number: CHE-9876265 NAK
  • NSF EPSCoR. Grant Number: EPS-0132534

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (302K)

Keywords:

  • Biocompatible materials;
  • Biomedical applications;
  • Carbon nanotubes, single-walled;
  • Layer-by-layer assembly;
  • Nanocomposites;
  • Neurons;
  • Thin films;
  • Tissue engineering

Graphical Abstract

Thumbnail image of graphical abstract

The first example of neural stimulation through a SWNT material assembled by layer-by-layer deposition is described (see figure). Excitation by lateral currents in the nanotube coating results in the opening of voltage-dependent Na+ ion channels. The experimental observations indicate the possibility of engineering of implantable biomedical devices from SWNT/polymer multilayers to be used for neuron prosthesis, pain management, and muscle stimulation.

Get PDF (302K)