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Advanced Materials

Stimulation of Neural Cells by Lateral Currents in Conductive Layer-by-Layer Films of Single-Walled Carbon Nanotubes

Authors

  • M. K. Gheith,

    1. Department of Physics, Oklahoma State University, 145 Physical Sciences Building, Stillwater, OK 74078-3072, USA
    2. Present address: Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA
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  • T. C. Pappas,

    1. Center for Biomedical Engineering, University of Texas Medical Branch, Jennie Sealy Hospital, Galveston, TX 77555-0144, USA
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  • A. V. Liopo,

    1. Center for Biomedical Engineering, University of Texas Medical Branch, Jennie Sealy Hospital, Galveston, TX 77555-0144, USA
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  • V. A. Sinani,

    1. Department of Chemical Engineering, Department of Biomedical Engineering, Department of Materials Science, University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109-2136, USA
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  • B. S. Shim,

    1. Department of Chemical Engineering, Department of Biomedical Engineering, Department of Materials Science, University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109-2136, USA
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  • M. Motamedi,

    1. Center for Biomedical Engineering, University of Texas Medical Branch, Jennie Sealy Hospital, Galveston, TX 77555-0144, USA
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  • J. P. Wicksted,

    1. Department of Physics, Oklahoma State University, 145 Physical Sciences Building, Stillwater, OK 74078-3072, USA
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  • N. A. Kotov

    1. Department of Chemical Engineering, Department of Biomedical Engineering, Department of Materials Science, University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109-2136, USA
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  • The authors thank the funding agencies including NSF BioPhotonics (BES-0119483 NAK, BES 0119544 MM), NSF CAREER award CHE-9876265 NAK) and NSF EPSCoR grant EPS-0132534. The authors thank Prof. Alexander A. Yaroslavov (M. V. Lomonosov Moscow State University) for his kind supply of the amphiphilic polymer used in the study. MKG and NAK thank Ms. Phoebi Doss for her assistance with SEM samples preparation.

Abstract

The first example of neural stimulation through a SWNT material assembled by layer-by-layer deposition is described (see figure). Excitation by lateral currents in the nanotube coating results in the opening of voltage-dependent Na+ ion channels. The experimental observations indicate the possibility of engineering of implantable biomedical devices from SWNT/polymer multilayers to be used for neuron prosthesis, pain management, and muscle stimulation.

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