A Room Temperature Ionic Liquid (RTIL)-Mediated, Non-Hydrolytic Sol–Gel Methodology to Prepare Molecularly Imprinted, Silica-Based Hybrid Monoliths for Chiral Separation


  • This work was supported by the National Natural Science Foundation of China (No. 20437020) and the National Basic Research Program of China (No. 2003CB415001).


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Silica-based hybrid molecularly imprinted polymer (MIP) monoliths with good chiral recognition ability are synthesized (see figure) using a novel method, a room temperature ionic liquid (RTIL)-mediated, non-hydrolytic sol–gel technique. The approach avoids the cracking and shrinking of the bed during drying, which is commonly associated with conventional sol–gel processing, overcomes the shortcomings associated with conventional organic-polymer-based MIP matrices, and offers improved selectivity.