Metal–Silica Hybrid Nanostructures for Surface-Enhanced Raman Spectroscopy


  • Funding from the Institute for Collaborative Biotechnologies through grant DAAD19-03D-0004 from the U.S. Army Research Office and from Lawrence Livermore National Laboratories through a UCDRD grant is gratefully acknowledged. This work made use of MRL Central Facilities supported by the MRSEC Program of the National Science Foundation under award No. DMR05-20415. S. W. B. acknowledges an NSF Graduate Research Fellowship. Helpful discussions with Anna Ivanowskaya and Dr. Peter Stoimenov are gratefully acknowledged. Supporting Information is available online from Wiley InterScience or from the author.


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The preparation of surface-enhanced Raman spectroscopy (SERS)-active substrates consisting of an ordered array of silver-tipped silica nanorods is reported (see figure and cover). Signal intensities obtained from test molecules are enhanced by factors of 10–20 for measurements on substrates consisting of small aggregates as compared to arrays of single particles. The reduced silver surface area of the hybrid system compared to other substrates is important to minimize the quantity of analyte necessary for detection.