We thank Professor Pierre Chambon (IGBMC, ICS, Collège de France, Strasbourg) for helpful discussions. This work was supported by the “Fondation de L'Avenir pour la Recherche Médicale Appliquée” and the “Ligue contre le Cancer (Région Alsace)”. N.J. is indebted to Bernard Senger for many fruitful and stimulating discussions and to Raphael Darcy (UCD, Dublin) for the generous gift of Cyclodextrin. Supporting Information is available online from Wiley InterScience or from the author.
Bone Formation Mediated by Synergy-Acting Growth Factors Embedded in a Polyelectrolyte Multilayer Film†
Article first published online: 27 FEB 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 19, Issue 5, pages 693–697, March, 2007
How to Cite
Dierich, A., Le Guen, E., Messaddeq, N., Stoltz, J.-F., Netter, P., Schaaf, P., Voegel, J.-C. and Benkirane-Jessel, N. (2007), Bone Formation Mediated by Synergy-Acting Growth Factors Embedded in a Polyelectrolyte Multilayer Film. Adv. Mater., 19: 693–697. doi: 10.1002/adma.200601271
- Issue published online: 27 FEB 2007
- Article first published online: 27 FEB 2007
- Manuscript Revised: 27 SEP 2006
- Manuscript Received: 9 JUN 2006
- Fondation de L'Avenir pour la Recherche Médicale Appliquée
- Ligue contre le Cancer (Région Alsace)
- Biomedical applications;
- Biomedical materials;
A bifunctionalized polyelectrolyte multilayer film (PEM film) that can drive embryonic stem cells to cartilage or bone differentiation is presented. A model system is constructed from a PEM film into which transforming growth factor β1 and bone morphogenetic protein has been embedded. The synergy between both factors is required for the film to be bioactive. Osteogenesis in embryonic stem cells is induced by the film (see figure).