Communication

Direct Printing of Bioceramic Implants with Spatially Localized Angiogenic Factors†

  1. U. Gbureck3,
  2. T. Hölzel3,
  3. C. J. Doillon2,
  4. F. A. Müller4,
  5. J. E. Barralet1

Article first published online: 27 FEB 2007

DOI: 10.1002/adma.200601370

Issue

Advanced Materials

Advanced Materials

Volume 19, Issue 6, pages 795–800, March, 2007

Additional Information

How to Cite

Gbureck, U., Hölzel, T., Doillon, C., Müller, F. and Barralet, J. (2007), Direct Printing of Bioceramic Implants with Spatially Localized Angiogenic Factors. Advanced Materials, 19: 795–800. doi: 10.1002/adma.200601370

Author Information

  1. 1

    Faculty of Dentistry, McGill University, Strathcona Anatomy & Dentistry Building, 3640 University St., Montréal, QC H3A 2B2, Canada

  2. 2

    Department of Surgery, Université Laval, Oncology and Molecular Endocrinology Research Centre, CHUL Research Centre, CHUQ, 2705 Boulevard Laurier, Québec City, QC G1V 4G2, Canada

  3. 3

    Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany

  4. 4

    Department for Materials Science III—Biomaterials, University of Erlangen–Nürnberg, Henkestr. 91, 91052 Erlangen, Germany

  1. †

    CJD and JEB contributed equally to this work. The authors acknowledge the technical assistance of Mr. J. Binette, Mrs. Renee Paradis and Mrs. Catherine Gerard, advice of Prof. Marc McKee and the financial support of Canada Research Chair program (J. E. B.), Québec Ministère des Relations Internationales (Québec-Bavaria Exchange Program) PSR-SIIRI-029 IBI. Supporting Information is available online from Wiley InterScience or from the author.

Publication History

  1. Issue published online: 9 MAR 2007
  2. Article first published online: 27 FEB 2007
  3. Manuscript Revised: 6 OCT 2006
  4. Manuscript Received: 21 JUN 2006

Funded by

  • Canada Research Chair program (J. E. B.)
  • Québec Ministère des Relations Internationales (Québec-Bavaria Exchange Program). Grant Number: PSR-SIIRI-029 IBI

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Keywords:

  • Bioceramics;
  • Biocompatible materials;
  • Copper;
  • Ink-jet printing

Graphical Abstract

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Direct printing of brushite and hydroxyapatite bioceramics at room temperature is used to construct model implants onto which the angiogenic compounds vascular endothelial growth factor (VEGF) and copper sulfate were adsorbed. This low-temperature direct approach offers several practical advantages and may find application in bone grafting. The figure shows examples of complex shapes made of brushite.

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