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Single-Molecule I2@US-Tube Nanocapsules: A New X-ray Contrast-Agent Design

Authors

  • J. M. Ashcroft,

    1. Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology, MS 60, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • K. B. Hartman,

    1. Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology, MS 60, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • K. R. Kissell,

    1. Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology, MS 60, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • Y. Mackeyev,

    1. Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology, MS 60, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • S. Pheasant,

    1. Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology, MS 60, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • S. Young,

    1. Department of Bioengineering, MS 142, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • P. A. W. Van der Heide,

    1. Center for Materials Chemistry, Department of Chemistry, University of Houston, 136 Fleming Bldg., Houston, TX 77204-5003, USA
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  • A. G. Mikos,

    1. Department of Bioengineering, MS 142, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • L. J. Wilson

    1. Department of Chemistry, Smalley Institute for Nanoscale Science and Technology, and the Center for Biological and Environmental Nanotechnology, MS 60, Rice University, P.O. Box 1892, Houston, TX 77251-1892, USA
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  • We thank the Robert A. Welch Foundation (Grant C-0627), the NASA Johnson Space Center, and University of Texas Health Center (Grant NNJ05HE75A) for support. We also thank Carbon Nanotechnologies, Inc. (Houston, Texas) for the gift of the HiPCO SWCNTs. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

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Single-molecule-like carbon nanocapsules derived from I2-filled ultrashort single-walled carbon nanotubes (US-tubes) have been prepared and characterized as a new paradigm in X-ray contrast-agent design. Functionalized by Bingel chemistry with external malonodiserinolamide  (Ser) groups, the new I2@US-tube (Ser)n species are water-soluble (0.25 mg mL–1) and more than twice as X-ray opaque as their empty US-tube(Ser) precursors.

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