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Forced Soft Lithography (FSL): Production of Micro- and Nanostructures in Thin Freestanding Sheets of Chitosan Biopolymer

Authors

  • J. G. Fernandez,

    1. Laboratory of Nanobioengineering—CIBER-BBN, Institut de bioenginyeria de Catalunya (IBEC), Barcelona Science Park, C/Josep Samitier 1–5, Barcelona 08028 (Spain)
    2. Department of Electronics, University of Barcelona, c/Martí i Franquès 1, 08028 Barcelona (Spain)
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  • C. A. Mills,

    1. Laboratory of Nanobioengineering—CIBER-BBN, Institut de bioenginyeria de Catalunya (IBEC), Barcelona Science Park, C/Josep Samitier 1–5, Barcelona 08028 (Spain)
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  • M. Pla-Roca,

    1. Laboratory of Nanobioengineering—CIBER-BBN, Institut de bioenginyeria de Catalunya (IBEC), Barcelona Science Park, C/Josep Samitier 1–5, Barcelona 08028 (Spain)
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  • J. Samitier

    1. Laboratory of Nanobioengineering—CIBER-BBN, Institut de bioenginyeria de Catalunya (IBEC), Barcelona Science Park, C/Josep Samitier 1–5, Barcelona 08028 (Spain)
    2. Department of Electronics, University of Barcelona, c/Martí i Franquès 1, 08028 Barcelona (Spain)
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  • We would like to thank D. Caballero Vila (Parc Cientific de Barcelona) for his help in the production of the AFM images in Figure 4. We also thank X. Sisquella (AFM), M.-J. Lopez Bosque (FIB), E. Martinez (FIB) and A. Errachid (DRIE) from the Parc Cientific de Barcelona for technical assistance with this work, as well as Dr. L. Fumagalli for her comments. Thanks also go to Drs. J. Bausells and G. Villanueva at the Centro Nacional de Microelectronica (Barcelona) for supplying the microstructured moulds used here. This paper and the work it concerns were generated in the context of the CellPROM project, funded by the European Community as contract N°. NMP4-CT-2004-500039 and it reflects only the authors' views. Support for this work from the Spanish Ministry for Science and Education through the provision of FPU (J. G. F.) and Ramon y Cajal (C. A. M.) grants is also gratefully acknowledged.

Abstract

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A “forced” soft lithography (FSL) technique is described for production of micro- and nanostructures into the surface of polymers at room temperature. The technique can be used with polymer/mould combinations that are unsuitable for conventional soft lithography, and has been used to structure the surface of the Chitosan biopolymer. Theoretical descriptions of the filling of the mould cavities and the possible formation of bubbles in the polymer are given.

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