Advanced Materials

Protein Detecting Arrays Based on Cationic Polythiophene–DNA-Aptamer Complexes


  • M. Béra Abérem and A. Najari contributed equally to this work. This work was supported by Génome Québec, Génome Canada, and the Natural Sciences and Engineering Research Council (NSERC) of Canada.


By combining an appropriate DNA aptamer with a cationic polythiophene optical transducer, human thrombin can be specifically detected on microarrays in the attomole range in less than one hour without any tagging of the target. The system can be modified and utilized as a probe for the detection of various proteins or other biomolecules. This work opens new interesting possibilities for simple and rapid multiparametric analysis in genomics and proteomics.

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