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Self-Assembly of a Dipeptide- Containing Conformationally Restricted Dehydrophenylalanine Residue to Form Ordered Nanotubes

Authors


  • M. Gupta and A. Bagaria contributed equally to this work. Financial support from the Department of Science and Technology, India is acknowledged. We thank the Department of Biotechnology, India for access to facilities at the Bioinformatics and the Interactive Graphics facility, IISc, Bangalore, and the core funding from ICGEB, New Delhi. The CCD diffractometer facility was supported under the IRPHA program of the Department of Science and Technology. M.G., A.B. and A.M. thanks the Council of Scientific and Industrial Research (CSIR) for fellowships. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

The self-assembly of a dehydrophenylalanine containing dipeptide (see figure), yielding highly ordered nanotubular structures, is discussed. The tubes are longer and thinner than previously reported peptide-based tubular structures; they are stable to boiling-water temperatures, different pH conditions, and to a highly nonspecific protease (Proteinase K).

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