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Keywords:

  • Biomaterials;
  • Biomedical applications;
  • Biomolecules;
  • Drug delivery;
  • Enzymes;
  • Hydrogels
Thumbnail image of graphical abstract

A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).