We acknowledge the support of the EPSRC in funding this project and Versamatrix for the gift of PEGA particles. We also wish to thank Robert Fernandez for his invaluable assistance with TPM and Ronan Magennis for his practical assistance.
Enzyme-Responsive Polymer Hydrogel Particles for Controlled Release†
Article first published online: 13 APR 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 19, Issue 9, pages 1252–1256, May, 2007
How to Cite
Thornton, P. D., Mart, R. J. and Ulijn, R. V. (2007), Enzyme-Responsive Polymer Hydrogel Particles for Controlled Release. Adv. Mater., 19: 1252–1256. doi: 10.1002/adma.200601784
- Issue published online: 27 APR 2007
- Article first published online: 13 APR 2007
- Manuscript Revised: 8 NOV 2006
- Manuscript Received: 4 AUG 2006
- Biomedical applications;
- Drug delivery;
A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).