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Enzyme-Responsive Polymer Hydrogel Particles for Controlled Release

Authors


  • We acknowledge the support of the EPSRC in funding this project and Versamatrix for the gift of PEGA particles. We also wish to thank Robert Fernandez for his invaluable assistance with TPM and Ronan Magennis for his practical assistance.

Abstract

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A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

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