Get access
Advanced Materials

Thermo and pH Dual-Responsive Nanoparticles for Anti-Cancer Drug Delivery

Authors

  • L. Zhang,

    1. Laboratory of Mesoscopic Chemistry and, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093 (P.R. China)
    Search for more papers by this author
  • R. Guo,

    1. Laboratory of Mesoscopic Chemistry and, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093 (P.R. China)
    Search for more papers by this author
  • M. Yang,

    1. Department of Oncology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, 210093 (P.R. China)
    Search for more papers by this author
  • X. Jiang,

    1. Laboratory of Mesoscopic Chemistry and, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093 (P.R. China)
    Search for more papers by this author
  • B. Liu

    1. Department of Oncology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing, 210093 (P.R. China)
    Search for more papers by this author

  • Supported by the Natural Science Foundation of China (No. 50625311, No. 50573031), the 973 Program of MOST (No. 2003CB615600) and the Cultivation Fund of MOE of China. L. Z. also gratefully acknowledges partial financial support from China Postdoctoral Science Foundation and Jiangsu Planned Projects for Postdoctoral Research Funds. Supporting Information is available online from Wiley InterScience or from the authors.

Abstract

Thermo and pH dual-responsive nanoparticles encapsulating an anti-cancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N-isopropylacrylamide-co-acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor-targeted anti-caner drug delivery.

original image
Get access to the full text of this article

Ancillary