Chemically Tunable Lensing of Stimuli-Responsive Hydrogel Microdomes


  • This work was supported by the National Institutes of Health (EB003072). J. D. E. acknowledges support from the National Science Foundation-Integrated Graduate Education Research Training program (NSF-IGERT) for a Predoctoral Fellowship.


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Chemically tunable hydrogel microlenses have been developed from acrylamide hydrogels based on covalently bound hinge-motion binding proteins, like calmodulin, and low affinity ligands, i.e. phenothiazine. Initially the protein binds to phenothiazine forming chemical crosslinks within the hydrogel, which are released in the presence of the higher affinity ligand chlorpromazine resulting in the swelling of the microlenses.