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Gold Nanoparticles Inhibit the Proliferation of Multiple Myeloma Cells

Authors


  • This work is supported by a CLL-Global Foundation grant to P.M. (CLL-2-2A3450) and a developmental grant from the Haem-malignancy program at the Mayo Clinic (RAF-20P) and partially supported by grant HL72178-05 to D.M. The authors are grateful to Prof. D. Mukhopadhyay and J. Charlesworth of the EM core facility at the Mayo Clinic for the TEM analysis. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose-dependent manner. Gold-treated multiple myeloma cells show cell-cycle arrest in the G1-phase (the phase when chromosomes prepare for replication) by up-regulation of cell-cycle cyclin-dependent kinase inhibitor proteins p21 and p27. Gold nanoparticles do not affect normal peripheral blood mononuclear cells.

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