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Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell-Adhesive Peptides


  • This research was supported by a grant from the United States National Institutes of Health (R01-EB004496). We thank Kenan Fears and Professor Robert A. Latour at Clemson University for assistance with ellipsometry measurements, and Dr. Brent Carter for assistance with XPS analyses. Supporting Information is available online from Wiley InterScience or from the author.


A monolayer of 11-(2-bromo-2-methyl)propionyloxy)undecenyldimethylchlorosilane on titanium serves as an initiator for surface-initiated atom-transfer polymerization of (oligoethylene glycol) methacrylate (OEGMA) to prepare poly(OEGMA) brushes. The polymer brush affords resistance to adhesion of osteoblastic cells. Treatment of the brush-modified surface with 4-nitrophenyl chloroformate followed by a GFOGER-containing peptide promotes cell adhesion, thereby representing a strategy to impart biofunctionality to titanium (see figure) and thereby promote osseointegration.

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