A monolayer of 11-(2-bromo-2-methyl)propionyloxy)undecenyldimethylchlorosilane on titanium serves as an initiator for surface-initiated atom-transfer polymerization of (oligoethylene glycol) methacrylate (OEGMA) to prepare poly(OEGMA) brushes. The polymer brush affords resistance to adhesion of osteoblastic cells. Treatment of the brush-modified surface with 4-nitrophenyl chloroformate followed by a GFOGER-containing peptide promotes cell adhesion, thereby representing a strategy to impart biofunctionality to titanium (see figure) and thereby promote osseointegration.
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