DNA-Based Self-Sorting of Nanoparticles on Gold Surfaces


  • Support by the DFG-funded Center for Functional Nanostructures at the University of Karlsruhe (TH) is gratefully acknowledged. The authors thank Albert Sugiharto for exploratory AFM experiments. Supporting Information is available online from Wiley InterScience or from the author. This contains information about materials, synthetic procedures, assay protocols, and analytical data.


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Site-selective deposition of nanoparticles onto surfaces is desirable for the fabrication of nanoscale devices. For nanoparticles with vastly different numbers of DNA chains on their surfaces, multivalent binding of short-sequence motifs and nonspecific adsorption complicate sequence-specific immobilization from mixtures. A new nanoparticle coating method that suppresses salt-induced aggregation and undesirable binding events is reported. Size-selective sorting of gold nanoparticles up to 60 nm diameter onto nanopatterned surfaces is shown (see figure).