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Keywords:

  • Biomaterials;
  • Biomimetics;
  • Cells;
  • Click chemistry;
  • Peptides;
  • Surface functionalization
Thumbnail image of graphical abstract

Versatile templates for gradient immobilization of biomolecules by click chemistry are easily generated from reproducible and tunable surface energy gradients. An arginine–glycine–aspartate (RGD) peptide density gradient controls cell adhesion (see figure), and demonstrates the utility of this fabrication process for making substrates that can screen cell response to bioactive materials.