Nanostructuring of a Titanium Material by High-Pressure Torsion Improves Pre-Osteoblast Attachment

Authors

  • S. Faghihi,

    1. Department of Biomedical Engineering, Center for Biorecognition and Biosensors, and Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 2B2 (Canada)
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  • A. P. Zhilyaev,

    1. Department of Physical Metallurgy, Centro National de Investigaciones Metallúrgicas (CENIM), CSIS 28040 Madrid (Spain)
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  • J. A. Szpunar,

    1. Department of Mining, Metals, and Materials Engineering, McGill University, Montreal, QC H3A 2B2 (Canada)
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  • F. Azari,

    1. Department of Biomedical Engineering, Center for Biorecognition and Biosensors, and Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 2B2 (Canada)
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  • H. Vali,

    1. Department of Biomedical Engineering, Center for Biorecognition and Biosensors, and Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 2B2 (Canada)
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  • M. Tabrizian

    1. Department of Biomedical Engineering, Center for Biorecognition and Biosensors, and Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 2B2 (Canada)
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  • We gratefully acknowledge the financial support of this work by grants from the Natural Science and Engineering Research Council (NSERC) of Canada and the Fonds Québécois de la recherche sur la nature et les technologies (FQRNT). The work was also partially supported by INTAS-03513779 and RFBR-05-03-32233-a. A.P.Z would like to thank the Spanish Ministry of Education and Science (under the Ramón y Cajal program) for financial support. In addition, we are grateful for the assistance and guidance of Dr. Kelly Sears, Line Mongeon (FIB and SEM), Slawomir Poplawski (XRD), and Suzie Poulin (XPS). Supporting Information is available online from Wiley InterScience or from the author.

Abstract

original image

Interaction of osteoblast and fibroblast cells with the surface of nanostructured titanium fabricated through high-pressure torsion (HPT) is reported. The underlying metallic nanostructure of an HPT-processed titanium substrate (see figure) affects the structure and composition of the thin oxide layer formed on the surface of these substrates. As a result, the physical and biological behavior of osteoblast cells toward the HPT-processed titanium substrates substantially improves (see inset).

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