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Advanced Materials

Graded-Bandgap Quantum- Dot-Modified Nanotubes: A Sensitive Biosensor for Enhanced Detection of DNA Hybridization


  • Helpful discussions with T. Basché are gratefully acknowledged. Financial support came from the Deutsche Forschungsgemeinschaft (partly through SFB 625: “Von einzelnen Molekülen zu nanoskopisch strukturierten Materialien”, and partly through CERC3, Mu 334/22-2: “A building-block approach for the study of transport and mechanism in confined environment: from synthesis to nano-organized design through controlled assembly”). Supporting Information is available online from Wiley or from the author.


Highly sensitive detection of DNA hybridization is demonstrated for the functionalized nanotubes (NTs) described here. With a cascaded-energy-transfer architecture produced by depositing, layer-by-layer, three types of ZnxCd1–xSe alloy quantum dots (QDs)—that is, graded-bandgap QDs—into ordered porous alumina membranes (see figure), the NTs provide the ability to detect small but significant changes in the signal during biological detection.

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