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Advanced Materials

Highly Stabilized Nucleotide-Capped Small Gold Nanoparticles with Tunable Size


  • This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), Sentinel: The Canadian Research Network on Bioactive Paper, and the Canadian Institutes for Health Research (CIHR). Y.L. holds a Canada Research Chair. Supporting Information is available online from Wiley InterScience or from the author.


Improved stability of gold nanoparticles (AuNPs) in water is achieved by capping the particles. Such stability improvements are significant because of the potential applications of AuNPs in various biologically relevant areas. The highly stabilized water-soluble AuNPs described in this study have precisely tunable sizes ranging from 2 to 5 nm (see figure; inset: fast Fourier transform) and a narrow monodispersity, and are prepared by using nucleotides as capping ligands.

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