Supramolecular Structures Generated by a p-tert-Butylphenyl-amide Derivative of Cholic Acid: From Vesicles to Molecular Tubes


  • The authors thank the Ministerio de Ciencia y Tecnología (Project MAT2004-04606) and Xunta de Galicia (PGIDIT05PXIC26201PN) for financial support. We also thank for the Acción Integrada Hispano–Italiana grant. Supporting Information is available online from Wiley InterScience or from the author.


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The formation of supramolecular structures initiated by a p-tert-butylphenyl-amide derivative of cholic acid is investigated. The initial spherical vesicles, with a rather low effective bending constant, collapse into necklaces that self-transform into tubules of small diameter. Finally, molecular tubes are generated (see figure). During the process, the geometrical constraints of fixed surface area and fixed enclosed volume are obeyed.