Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks


  • This work was supported by the National Institutes of Health (NIH-NIAID R21 AI62445-01). Supporting Information is available online from Wiley InterScience or from the authors.


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Dynamically restructuring hydrogel networks are formed from two water-soluble polymers by functionalization with phenylboronic acid (PBA) and salicylhydroxamic acid (SHA) moieties that interact through pH-sensitive and reversible covalent crosslinks (see figure). The networks can be tuned to display a wide range of pH-responsive properties, which can potentially be exploited for drug delivery systems in biological environments where similar acidic changes occur.