Research support from an NIST Innovation in Measurement Science Award for Carbon Nanotube Metrology and NIST/National Research Council postdoctoral fellowships (N.D.G. and J.A.F.) are gratefully acknowledged.
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Communication
Length-Dependent Uptake of DNA-Wrapped Single-Walled Carbon Nanotubes†
Article first published online: 20 MAR 2007
DOI: 10.1002/adma.200602667
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Becker, M. L., Fagan, J. A., Gallant, N. D., Bauer, B. J., Bajpai, V., Hobbie, E. K., Lacerda, S. H., Migler, K. B. and Jakupciak, J. P. (2007), Length-Dependent Uptake of DNA-Wrapped Single-Walled Carbon Nanotubes. Adv. Mater., 19: 939–945. doi: 10.1002/adma.200602667
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Publication History
- Issue published online: 29 MAR 2007
- Article first published online: 20 MAR 2007
- Manuscript Revised: 22 JAN 2007
- Manuscript Received: 22 NOV 2006
Funded by
- NIST Innovation in Measurement Science Award for Carbon Nanotube Metrology
- Abstract
- References
- Cited By
Keywords:
- Biocompatibility;
- Carbon nanotubes, functionalized;
- Carbon nanotubes, single-walled;
- Cells;
- DNA wrapping;
- Separation;
- Toxicity, in vitro
A length threshold for cell uptake of DNA-wrapped single-walled carbon nanotubes (SWNTs) by human lung fibroblasts (IMR90) is identified. Competitive uptake experiments with well-defined and characterized length fractions show that SWNTs above the length threshold are excluded from the cell, whereas SWNTs labeled with Cy3-derivatized DNA below the threshold are able to access the cell interior, as shown in the fluorescence image and on the cover.