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Length-Dependent Uptake of DNA-Wrapped Single-Walled Carbon Nanotubes


  • Research support from an NIST Innovation in Measurement Science Award for Carbon Nanotube Metrology and NIST/National Research Council postdoctoral fellowships (N.D.G. and J.A.F.) are gratefully acknowledged.


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A length threshold for cell uptake of DNA-wrapped single-walled carbon nanotubes (SWNTs) by human lung fibroblasts (IMR90) is identified. Competitive uptake experiments with well-defined and characterized length fractions show that SWNTs above the length threshold are excluded from the cell, whereas SWNTs labeled with Cy3-derivatized DNA below the threshold are able to access the cell interior, as shown in the fluorescence image and on the cover.

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