Thermoresponsive “Particle Pumps”: Activated Release of Organic Nanoparticles from Open-Cell Macroporous Polymers


  • This work was supported by the EPSRC (EP/C511794/1) and University of Liverpool (RDF 6014). HZ is a RCUK Academic Fellow. AIC is a Royal Society University Research Fellow. We acknowledge Dr. Jim Long and Dr. Dong Wang (IOTA NanoSolutions) for assistance with DLS measurement and AFM imaging, respectively. Supporting Information is available online from Wiley InterScience or from the author.


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Organic (drug) nanoparticles are formed by a freeze–dry process in  situ inside the emulsion-templated temperature-senstive polymeric materials. These nanoparticles could be pumped into water to form stable nanodispersions on demand simply by raising the surrounding temperature above 30 °C, while there were no particles released at room temperatures below 20 °C.