Cover Picture: Protein Detecting Arrays Based on Cationic Polythiophene–DNA-Aptamer Complexes (Adv. Mater. 20/2006)



The cover image depicts biochips based on responsive nanoaggregates made from stoichiometric complexes between a cationic polythiophene and an appropriate DNA aptamer. These structures undergo a conformational transition from an unfolded to a folded (G-quadruplex) structure in the presence of a specific target protein that results in a significant increase of the fluorescence intensity, as reported on p. 2703 by Leclerc and co-workers.