Endothelialization of Titanium Surfaces


  • M. W. G. and D. J. K. would like to thank the NIH for funding (R01-EB-000501). We thank the team at Affinergy Inc. for useful discussions, especially Dr. Greg Harbers for performing XPS studies, the technical staff at the Shared Materials Instrumentation Facility at Duke University for useful technical advice, and Xiaojuan Khoo of BU for the Ti coated glass slides. S. R. M. would like to thank the NIH Training Program in Quantitative Biology and Physiology at Boston University.


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An interfacial peptide coating possessing domains that bind to Ti and endothelial cells is synthesized (see figure). Peptides with specific adherence to Ti are identified using phage display, and the RGD motif was selected for cell binding. The peptide can be applied from aqueous solution and possesses micromolar binding affinities. The coating significantly enhances endothelial cell adhesion and spreading under both static and dynamic conditions.