Communication

Biospecific Recognition of Tethered Small Molecules Diluted in Self-Assembled Monolayers†

  1. M. J. Shuster2,
  2. A. Vaish3,
  3. M. E. Szapacs4,5,
  4. M. E. Anderson4,
  5. P. S. Weiss2,4,
  6. A. M. Andrews1

Article first published online: 7 DEC 2007

DOI: 10.1002/adma.200700082

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 1, pages 164–167, January, 2008

Additional Information

How to Cite

Shuster, M., Vaish, A., Szapacs, M., Anderson, M., Weiss, P. and Andrews, A. (2008), Biospecific Recognition of Tethered Small Molecules Diluted in Self-Assembled Monolayers. Advanced Materials, 20: 164–167. doi: 10.1002/adma.200700082

Author Information

  1. 1

    Huck Institutes of the Life Sciences and Department of Veterinary & Biomedical Sciences, Pennsylvania State University, 201 Life Sciences Building, University Park, PA 16802 (USA)

  2. 2

    Department of Physics, Pennsylvania State University, University Park, PA 16802 (USA)

  3. 3

    Department of Bioengineering, Pennsylvania State University, University Park, PA 16802 (USA)

  4. 4

    Department of Chemistry, Pennsylvania State University, University Park, PA 16802 (USA)

  5. 5

    Current address: GlaxoSmithKline, Worldwide Bioanalysis (DMPK), King of Prussia, PA 19406, USA

  1. †

    The authors gratefully acknowledge support from the NSF-funded PSU MRSEC, and Profs. P. Bevilacqua, R. Funk, C. Keating, M. Mrksich, and M. Pishko for helpful discussions. Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 28 DEC 2007
  2. Article first published online: 7 DEC 2007
  3. Manuscript Revised: 28 AUG 2007
  4. Manuscript Received: 10 JAN 2007

Funded by

  • NSF-funded PSU MRSEC

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Keywords:

  • Biosensors;
  • Self-assembled monolayers

Graphical Abstract

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We describe the first in a series of studies designed to develop and to characterize self-assembled monolayers containing isolated small-molecule probes. We insert tether molecules into preformed oligo(ethylene glycol)-terminated alkanethiolate monolayer matrices and covalently attach the neurotransmitter serotonin to the tethers. These monolayers selectively recognize serotonin antibodies and resist binding of nonspecific antibodies and proteins. We will use these capture materials for biosensor development and functionally-directed proteomics.

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