Communication

Remotely Triggered Release from Magnetic Nanoparticles†

  1. A. M. Derfus1,2,
  2. G. von Maltzahn1,4,
  3. T. J. Harris1,4,
  4. T. Duza2,
  5. K. S. Vecchio3,
  6. E. Ruoslahti2,5,
  7. S. N. Bhatia1,4

Article first published online: 15 NOV 2007

DOI: 10.1002/adma.200700091

Issue

Advanced Materials

Advanced Materials

Volume 19, Issue 22, pages 3932–3936, November, 2007

Additional Information

How to Cite

Derfus, A., von Maltzahn, G., Harris, T., Duza, T., Vecchio, K., Ruoslahti, E. and Bhatia, S. (2007), Remotely Triggered Release from Magnetic Nanoparticles. Advanced Materials, 19: 3932–3936. doi: 10.1002/adma.200700091

Author Information

  1. 1

    Department of Bioengineering, University of California, San Diego, CA (USA)

  2. 2

    Burnham Institute of Medical Research, La Jolla, CA (USA)

  3. 3

    Department of NanoEngineering, Jacobs School of Engineering, University of California, San Diego, CA (USA)

  4. 4

    Current address: Harvard-M.I.T. Division of Health Sciences and Technology, Division of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, and Division of Medicine, Brigham & Women's Hospital, 77 Massachusetts Ave. E19-502D, Cambridge, MA 02139, USA

  5. 5

    Current address: Burnham Institute for Medical Research at University of California, Santa Barbara, CA 93106-9610, USA

  1. †

    The authors thank Miriam Scadeng for MR imaging and acknowledge financial support of the David and Lucile Packard Foundation, the National Cancer Institute of the National Institutes of Health (N01-C0-37117, U54 CA119349-01, U54 CA119335, 1 R01 CA124427-01). AMD thanks the UC Biotechnology Research and Education Program for a G.R.E.A.T. fellowship (#2004-16). The authors declare no competing financial interests.

Publication History

  1. Issue published online: 15 NOV 2007
  2. Article first published online: 15 NOV 2007
  3. Manuscript Revised: 18 JUN 2007
  4. Manuscript Received: 11 JAN 2007

Funded by

  • David and Lucile Packard Foundation
  • National Cancer Institute of the National Institutes of Health. Grant Numbers: N01-C0-37117, U54 CA119349-01, U54 CA119335, 1 R01 CA124427-01
  • UC Biotechnology Research and Education Program. Grant Number: 2004-16

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Keywords:

  • Controlled release;
  • Drug delivery;
  • Magnetic nanoparticles

Graphical Abstract

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Multifunctional nanoparticles are multivalent, remotely-actuated, and imaged non-invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat-labile tethers to release model drugs in vivo (see figure).

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