Aggregation-Enhanced Fluorescence in Organically Modified Silica Nanoparticles: A Novel Approach toward High-Signal-Output Nanoprobes for Two-Photon Fluorescence Bioimaging


  • This work was supported in part by a grant from the the John R. Oishei Foundation and in part by a grant from the Directorate of Chemistry and Life Sciences of the Air Force Office of Scientific Research. Supporting Information is available online from Wiley InterScience or from the authors.


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Phase-separated nanoaggregation of a highly loaded 9,10-bis[4'-(4''-aminostyryl)styryl]anthracene dye in organically modified silica (ORMOSIL) nanoparticles boosts intracellular two-photon fluorescence signal by virtue of enhanced two-photon absorption and emission, high chromophore number density in the nano-space, and noninvasive cellular uptake.