Optical Analysis of Beads Encoded with Quantum Dots Coated with a Cationic Polymer


  • The authors would like to thank X. Xu for assistance with TEM imaging. C. N. A. acknowledges the financial support from Le Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT) and from the Natural Sciences and Engineering Research Council of Canada (NSERC). B. D. would like to thank the Région Ile de France and the Human Frontier Science Program for funding. Supporting Information is available online from Wiley InterScience or from the author.


original image

Quantum dots are incorporated onto small beads made of various materials thanks to the versatile layer-by-layer method. The high contrast, tri-color gradient TEM image of a bead emphasizes quantum dots in red-yellow spots. Below, quantum dot coated magnetic beads demonstrate bimodality with their bright fluorescence and alignment along field lines. An hyperspectral imaging inspired technique allowed faster statistical characterization of optically coded beads on a setup typical of biological experiments.