This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-003-D00040) and the Micro Thermal System Research Center of Seoul National University. This work was also supported by Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation. The authors are grateful to the Minuta Tech. for providing polyurethane acrylate materials.
Molded Nanowell Electrodes for Site-Selective Single Liposome Arrays†
Article first published online: 11 DEC 2007
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 20, Issue 1, pages 31–36, January, 2008
How to Cite
Kim, P., Lee, B. K., Lee, H. Y., Kawai, T. and Suh, K. Y. (2008), Molded Nanowell Electrodes for Site-Selective Single Liposome Arrays. Adv. Mater., 20: 31–36. doi: 10.1002/adma.200700570
- Issue published online: 28 DEC 2007
- Article first published online: 11 DEC 2007
- Manuscript Revised: 16 MAY 2007
- Manuscript Received: 7 MAR 2007
- Korea Research Foundation Grant
- Korean Government (MOEHRD, Basic Research Promotion Fund). Grant Number: KRF-2006-003-D00040
- Micro Thermal System Research Center of Seoul National University
- Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation
We present a nanowell (NW)-based biosensing platform for electrochemically detecting biological reactions on the level of single lipid vesicle. The NW geometry of a gently-sloped vertical wall is found to be optimal for selective deposition of single liposomes without capillary resistances. Also, the use of a hydrophilic, non-biofouling PEG copolymer is essential to provide distinctively separated FLV arrays without nonspecific adsorption.