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Advanced Materials

Polyelectrolyte Coatings with a Potential for Electronic Control and Cell Sheet Engineering

Authors

  • O. Guillaume-Gentil,

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092 Zurich (Switzerland)
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  • Y. Akiyama,

    1. Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666 (Japan)
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  • M. Schuler,

    1. Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zürich (Switzerland)
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  • C. Tang,

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092 Zurich (Switzerland)
    2. Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zürich (Switzerland)
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  • M. Textor,

    1. Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zürich (Switzerland)
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  • M. Yamato,

    1. Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666 (Japan)
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  • T. Okano,

    1. Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666 (Japan)
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  • J. Vörös

    1. Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, 8092 Zurich (Switzerland)
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  • This work was supported by the Roche Research Foundation (Mkl/stm 39-2005), the Competence Centre for Materials Science and Technology, and the Germaine de Staël program for Franco-Swiss collaboration. Prof. P. Schaaf (Institut Charles Sadron, Strasbourg, France), Dr. J. C. Voegel (INSERM, Strasbourg, France), and the members of their groups are acknowledged for valuable discussions. We thank M. Elsener (Laboratory of Surface Science and Technology, ETH Zurich) for the fabrication of the PEEK flow cell, and J. Steinhauser (Institute of Microtechnology, University of Neuchâtel, Switzerland) for his assistance with ITO sputter-coating. Supporting Information is available online from Wiley InterScience or from the authors.

Abstract

A novel method for non-invasive cell sheet recovery based on polyelectrolyte thin films is presented. Coatings with highly tunable properties allow for controlling the cell surface interactions or can be used as electronically switchable sacrificial layer offering a promising new tool for cell sheet based tissue engineering.

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