Communication

Biomimetic pH Sensitive Polymersomes for Efficient DNA Encapsulation and Delivery†

  1. H. Lomas1,
  2. I. Canton1,
  3. S. MacNeil1,
  4. J. Du2,
  5. S. P. Armes2,
  6. A. J. Ryan2,
  7. A. L. Lewis3,
  8. G. Battaglia1

Article first published online: 12 NOV 2007

DOI: 10.1002/adma.200700941

Issue

Advanced Materials

Advanced Materials

Volume 19, Issue 23, pages 4238–4243, December, 2007

Additional Information

How to Cite

Lomas, H., Canton, I., MacNeil, S., Du, J., Armes, S., Ryan, A., Lewis, A. and Battaglia, G. (2007), Biomimetic pH Sensitive Polymersomes for Efficient DNA Encapsulation and Delivery. Advanced Materials, 19: 4238–4243. doi: 10.1002/adma.200700941

Author Information

  1. 1

    Biomaterials and Tissue Engineering Group, Department of Engineering Materials, The Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield, S3 7HQ (UK)

  2. 2

    Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S37HF (UK)

  3. 3

    Biocompatibles UK Ltd., Chapman House, Farnham Business Park, Weydon Lane, Farnham, Surrey GU9 8QL (UK)

  1. †

    We thank the Department of Engineering Materials, University of Sheffield for funding part of this work. SPA is the recipient of a five-year Royal Society-Wolfson Research Merit Award. Irene Canton is funded by BBSRC. Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 28 NOV 2007
  2. Article first published online: 12 NOV 2007
  3. Manuscript Revised: 19 JUN 2007
  4. Manuscript Received: 19 APR 2007

Funded by

  • Department of Engineering Materials, University of Sheffield

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (545K)

Keywords:

  • Biomimetics;
  • DNA;
  • Encapsulation;
  • Gene therapy;
  • Polymersomes;
  • Stimuli-responsive materials

Graphical Abstract

Thumbnail image of graphical abstract

A novel gene delivery vector based on the ability of a synthetic amphiphilic block copolymer to mimic biological phospholipids by forming membrane-enclosed structures, specifically nanometer-sized vesicles, is presented. A pH-sensitive diblock copolymer forms vesicles (polymersomes) at neutral pH, and dissolves completely as unimers at endocytic pH (see figure). GFP-encoding plasmid DNA are successfully encapsulated inside the polymer vesicles, and delivered intracellularly.

Get PDF (545K)