The authors thank the National Institute of Health (R01 NS045072) for support of this study. T.M.S. thanks the Undergraduate Research Scholars program from Georgia Tech/Emory Center for the Engineering of Living Tissues (funded by the National Science Foundation).
A Novel Anti-inflammatory Surface for Neural Electrodes†
Article first published online: 16 OCT 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 19, Issue 21, pages 3529–3533, November, 2007
How to Cite
He, W., McConnell, G. C., Schneider, T. M. and Bellamkonda, R. V. (2007), A Novel Anti-inflammatory Surface for Neural Electrodes. Adv. Mater., 19: 3529–3533. doi: 10.1002/adma.200700943
- Issue published online: 5 NOV 2007
- Article first published online: 16 OCT 2007
- Manuscript Revised: 22 JUN 2007
- Manuscript Received: 19 APR 2007
- National Institute of Health. Grant Number: R01 NS045072
- Biocompatible materials;
- Biomedical materials;
An inherently anti-inflammatory surface for neural electrodes is fabricated by immobilization of a neuroimmunomodulatory peptide alpha-MSH. In vitro cell studies and in vivo rodent studies demonstrate that the tethered peptide retains its anti-inflammatory properties, and is able to directly modulate microglial response by modulating the expression of inflammatory cytokine (see figure), thereby suggesting the potential of this strategy to improve the reliability of chronic neural implants in vivo.