Design of Contact-Active Antimicrobial Acrylate-Based Materials Using Biocidal Macromers


  • The authors thank the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie for financial support. We are grateful to Dr. Klaus Pelz for providing the S. aureus cells and to Julia M. Weiss for bacterial testing.


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A self organizing antimicrobial finish on acrylate-based materials was achieved by adding only 0.4 wt% of a biocidal macromer to the monomer mixture prior polymerization. The materials surface kills the infectious bacterium Staphylococcus aureus without releasing the biocide (Figure, lower section) and stays active even after 45 d of constant washing. Confocal Raman spectroscopy and fluorescence microscopy (Figure, upper section) reveal that the biocide has migrated to the surface of the materials during polymerization.