Minimally Invasive Protein Delivery with Rapidly Dissolving Polymer Microneedles


  • We thank Harvinder Gill, Michael Heffernan, Jung-Hwan Park and Genggeng Qi for helpful discussions. MRP is the Emerson–Lewis Faculty Fellow. This work was carried out at the Institute for Bioengineering and Bioscience and the Center for Drug Design, Development and Delivery at Georgia Tech. This work was supported in part by the Southeast Regional Center of Excellence for Emerging Infections and Biodefense and the National Institutes of Health.


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A new room-temperature, in situ polymerization process to produce microneedles (see figure), which can encapsulate functional biomolecules and dissolve within minutes, is presented. The dissolution rate and mechanical strength of these polymer microneedles can be tailored by changing monomer composition and microneedle geometry. Drug delivery using micrometer-scale needles that dissolve in the skin could eliminate the pain and dangers of hypodermic needle use.