Communication

Cartilage Tissue Engineering in Plasma and Whole Blood Scaffolds†

  1. Marcus Haberhauer1,
  2. Göran Zernia2,
  3. Andrea Deiwick1,
  4. Claudia Pösel1,
  5. Augustinus Bader1,
  6. Daniel Huster2,
  7. Ronny M. Schulz1,*

Article first published online: 29 APR 2008

DOI: 10.1002/adma.200701344

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 11, pages 2061–2067, June 4, 2008

Additional Information

How to Cite

Haberhauer, M., Zernia, G., Deiwick, A., Pösel, C., Bader, A., Huster, D. and Schulz, R. M. (2008), Cartilage Tissue Engineering in Plasma and Whole Blood Scaffolds. Advanced Materials, 20: 2061–2067. doi: 10.1002/adma.200701344

Author Information

  1. 1

    Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, 04103 Leipzig (Germany)

  2. 2

    Institute of Medical Physics and Biophysics, University of Leipzig Härtelstr. 16-18, 04107 Leipzig (Germany)

*Department of Cell Techniques and Applied Stem Cell Biology, University of Leipzig, Deutscher Platz 5, 04103 Leipzig (Germany).

  1. †

    This work was supported by the European Funds for Regional Development (EFRE, Project: #4212/03-12), by the German Research Foundation (Project BA 1025/2-1, HU 720/7-1) and by the German Ministry of Education and Research (BMBF Grant 0313836). Supporting Information is available online from Wiley InterScience or from the author.

Publication History

  1. Issue published online: 5 JUN 2008
  2. Article first published online: 29 APR 2008
  3. Manuscript Revised: 14 NOV 2007
  4. Manuscript Received: 4 JUN 2007

Funded by

  • Regional Development (EFRE). Grant Number: #4212/03-12
  • German Research Foundation. Grant Numbers: BA 1025/2-1, HU 720/7-1
  • German Ministry of Education and Research (BMBF). Grant Number: 0313836

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Keywords:

  • cells;
  • tissue engineering;
  • biomedical applications;
  • biomaterials

Graphical Abstract

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Plasma and whole blood based scaffolds were used for cartilage tissue engineering. Chondrocytes were isolated, embedded into these structures, and cultivated for two weeks. To evaluate the neo-synthesized extracellular matrix quantitatively, the constructs were examined by classical techniques and NMR spectroscopy. Significant expression of characteristic extracellular matrix was found suggesting that these materials are well-suited grafts for artificial tissue.

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