Localized “Click” Chemistry Through Dip-Pen Nanolithography


  • We gratefully acknowledge W. Volksen and J. Koerner for the gas-phase silylations, M. Bersani, W. Hinsberg, J. Sly, and C. Hawker for helpful discussions, and financial support from DoD, NSF (CHE0552961), and IBM. Supporting Information is available online from Wiley InterScience or from the authors.


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Local reactions are triggered by delivering molecules from an AFM probe tip, allowing for direct modification of chemically functionalized surfaces. Silicon wafer-bound acetylene moieties readily undergo 1,3-dipolar cycloadddition with solution-phase azides delivered from an AFM tip. This selective and robust technique allows for the facile creation and placement of sub-micrometer-sized features.