Communication

Highly Emissive Self-assembled Organic Nanoparticles having Dual Color Capacity for Targeted Immunofluorescence Labeling†

  1. Hyong-Jun Kim1,5,
  2. Jiseok Lee3,
  3. Tae-Hoon Kim1,4,
  4. Taek Seung Lee4,
  5. Jinsang Kim1,2,3,*

Article first published online: 29 FEB 2008

DOI: 10.1002/adma.200701601

Issue

Advanced Materials

Advanced Materials

Volume 20, Issue 6, pages 1117–1121, March 18, 2008

Additional Information

How to Cite

Kim, H.-J., Lee, J., Kim, T.-H., Lee, T. S. and Kim, J. (2008), Highly Emissive Self-assembled Organic Nanoparticles having Dual Color Capacity for Targeted Immunofluorescence Labeling. Advanced Materials, 20: 1117–1121. doi: 10.1002/adma.200701601

Author Information

  1. 1

    Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  2. 2

    Chemical Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  3. 3

    Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)

  4. 4

    Department of Advanced Organic Materials and Textile System, Engineering Chungnam National University, Daejon, 305-764 (Korea)

  5. 5

    Current address: OLED center, School of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea.

*Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109 (USA).

  1. †

    H.-J.K. and J.L. contributed equally to this work. This research was supported by the National Science Foundation (BES 0428010), NSF CAREER Award (DMR 0644864), and the Center for Chemical Genomics-Thermo Fisher Grant. T.-H.K. acknowledges Korea Science and Engineering Foundation (KOSEF) for the exchange student support. Supporting Information is available online from Wiley InterScience or from the authors.

Publication History

  1. Issue published online: 19 MAR 2008
  2. Article first published online: 29 FEB 2008
  3. Manuscript Revised: 27 SEP 2007
  4. Manuscript Accepted: 27 SEP 2007
  5. Manuscript Received: 4 JUL 2007

Funded by

  • National Science Foundation. Grant Number: BES 0428010
  • Center for Chemical Genomics-Thermo Fisher Grant

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (253K)

Keywords:

  • Organic Nanoparticles;
  • Self-assembly;
  • ESIPT;
  • Immunofluorescence

Graphical Abstract

Thumbnail image of graphical abstract

A new benzoxazole molecule has been synthesized and self-assembled with functionalized diacetylene molecules to obtain well-defined nanoparticles of 80 nm diameter. The nanoparticles show enhanced fluorescence emission of 38% quantum yield compared to 3% in THF solution. Selective targeting and dual color visualization of patterned avidin arrays were achieved by using these nanoparticles to demonstrate their promising application for immunofluorescence labeling.

Get PDF (253K)