Self-Assembly of Cell–Microparticle Hybrids


  • This work was supported by the American Cancer Society under grant number IRG-77-004-28.


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Synthetic-biological hybrids of biodegradable microparticles and transfected cells are assembled, as schematically illustrated in the figure. The cells are surface-functionalized with biotin and the particle surface is also engineered with biotin. Avidin is then used as a bridging protein to bind together the microparticles and the surface- functionalized cells.