This work was supported by the Georgia Institute of Technology, NIH Grant 1R21 EB008565-01A1 (Y. W.) and the National Science Foundation Graduate Research Fellowship (C. B. G.). We thank Marcus Foston and Matthew DiPrima for assistance with GPC and DSC, Dr. Jin Gao for assistance with DRG isolation, Karun Somani and Miyu Toyoshima for merging images for analysis. We also thank Richard Cross for help with statistical analysis.
Modulating Neuronal Responses by Controlled Integration of Acetylcholine-like Functionalities in Biomimetic Polymers†
Article first published online: 11 DEC 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 19, Issue 24, pages 4404–4409, December, 2007
How to Cite
Gumera, C. B. and Wang, Y. (2007), Modulating Neuronal Responses by Controlled Integration of Acetylcholine-like Functionalities in Biomimetic Polymers. Adv. Mater., 19: 4404–4409. doi: 10.1002/adma.200701747
- Issue published online: 11 DEC 2007
- Article first published online: 11 DEC 2007
- Manuscript Revised: 20 SEP 2007
- Manuscript Received: 17 JUL 2007
- Georgia Institute of Technology. Grant Number: 1R21 EB008565-01A1
- National Science Foundation Graduate Research Fellowship (C. B. G.)
This paper describes a new pathway to neuroactive materials that relies on integration of neurotransmitter-like functional groups into synthetic polymers. A series of biodegradable polymers are synthesized with varying concentrations of acetylcholine-like functionalities (ALFs) using a modular design. The polymers with medium ALF contents resemble laminin in promoting neurite sprouting and extension while maintaining phenotypic protein expression of neurons.