Gold Nanoparticles Induce Oxidative Damage in Lung Fibroblasts In Vitro


  • The authors would like to thank the National University of Singapore (NUS) and Office of Life Sciences (OLS) for funding support (R-279-000-205-112 and R-398-000-035-712), and NUS Nanoscience and Nanotechnology Initiative (NUSNNI) for administrative support. The Supporting Information contains optical microscopy images of all cell culture results, magnified TEM images, EDAX analysis, and gene names and descriptions of significantly downregulated genes in real time PCR array. Supporting Information is available online from Wiley InterScience or from the author.


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Evaluation of the health risks associated with the use of nanometer-sized particles constitutes an important research field. Here, the effect of gold nanoparticles (AuNPs) on human embryonic lung fibroblasts is investigated. The figure shows the uptake of AuNPs by lung fibroblasts. Most nanoparticles are endocytosed and found in vesicles (arrows) around the nucleus (N). However, some particles are found in cytosol (red circle).