Communication

Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery†

  1. Y.-M. Huh1,
  2. E.-S. Lee1,
  3. J.-H. Lee2,
  4. Y.-w. Jun2,
  5. P.-H. Kim3,
  6. C.-O. Yun3,
  7. J.-H. Kim3,
  8. J.-S. Suh1,
  9. J. Cheon2

Article first published online: 17 OCT 2007

DOI: 10.1002/adma.200701952

Issue

Advanced Materials

Advanced Materials

Special Issue: Special Section on Bionanotechnology

Volume 19, Issue 20, pages 3109–3112, October, 2007

Additional Information

How to Cite

Huh, Y.-M., Lee, E.-S., Lee, J.-H., Jun, Y.-w., Kim, P.-H., Yun, C.-O., Kim, J.-H., Suh, J.-S. and Cheon, J. (2007), Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery. Adv. Mater., 19: 3109–3112. doi: 10.1002/adma.200701952

Author Information

  1. 1

    Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752 (Korea)

  2. 2

    Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)

  3. 3

    Brain Korea 21 Projects for Medical Science, Institute for Cancer Research, Yonsei Cancer Center, College of Medicine, Yonsei University, Seoul 120-752 (Korea)

  1. †

    We would like to thank Dr. Y. J. Kim, J.-G. Kim, H. S. Kwon, and J. M. Oh for the TEM analyses (KBSI). This work is supported in part by the Korea Health 21 Research and Development Project (A06-00043433), the National Research Laboratory (NRL-2006-00457), NCI Center for Cancer Nanotechnology Excellence, Nanomedical National Core Research Center (R15-2004-024-00000-0), AOARD (FA520906P0170), KOSEF (R01-2006-000-10023-9), and BK-21 Project of Chemistry and Medicine.

Publication History

  1. Issue published online: 17 OCT 2007
  2. Article first published online: 17 OCT 2007
  3. Manuscript Received: 3 AUG 2007

Funded by

  • Korea Health 21 Research and Development Project. Grant Number: A06-00043433
  • National Research Laboratory. Grant Number: NRL-2006-00457
  • NCI Center for Cancer Nanotechnology Excellence
  • Nanomedical National Core Research Center. Grant Number: R15-2004-024-00000-0
  • AOARD. Grant Number: FA520906P0170
  • KOSEF. Grant Number: R01-2006-000-10023-9
  • BK-21 Project of Chemistry and Medicine

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Keywords:

  • Gene delivery;
  • Hybrid materials;
  • Magnetic nanoparticles;
  • Viruses
Thumbnail image of graphical abstract

Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.

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