Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery


  • We would like to thank Dr. Y. J. Kim, J.-G. Kim, H. S. Kwon, and J. M. Oh for the TEM analyses (KBSI). This work is supported in part by the Korea Health 21 Research and Development Project (A06-00043433), the National Research Laboratory (NRL-2006-00457), NCI Center for Cancer Nanotechnology Excellence, Nanomedical National Core Research Center (R15-2004-024-00000-0), AOARD (FA520906P0170), KOSEF (R01-2006-000-10023-9), and BK-21 Project of Chemistry and Medicine.


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Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.