This work was supported by grants from the U.S. Environmental Protection Agency (RD-83172201-0) and the Department of Defence (MURI FA9550-04-1-0430).
Testing Nanomaterials of Unknown Toxicity: An Example Based on Platinum Nanoparticles of Different Shapes†
Article first published online: 17 OCT 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Special Section on Bionanotechnology
Volume 19, Issue 20, pages 3124–3129, October, 2007
How to Cite
Elder, A., Yang, H., Gwiazda, R., Teng, X., Thurston, S., He, H. and Oberdörster, G. (2007), Testing Nanomaterials of Unknown Toxicity: An Example Based on Platinum Nanoparticles of Different Shapes. Adv. Mater., 19: 3124–3129. doi: 10.1002/adma.200701962
- Issue published online: 17 OCT 2007
- Article first published online: 17 OCT 2007
- Manuscript Received: 7 AUG 2007
- U.S. Environmental Protection Agency. Grant Number: RD-83172201-0
- Department of Defence. Grant Number: MURI FA9550-04-1-0430
- Inorganic nanoparticles;
Human endothelial and lung epithelial cells were exposed to nanosized Pt shapes following acellular analyses of their oxidant potential. Despite clear evidence of particle uptake by cells, the Pt nanoparticles were not found to induce cytotoxicity or oxidative stress in either cell type. Results from in vivo respiratory tract exposures suggest that the particles are retained by lung tissue and that minimal-mild lung inflammation results from exposure to the nanosized Pt particles.