This work was supported by grants from the U.S. Environmental Protection Agency (RD-83172201-0) and the Department of Defence (MURI FA9550-04-1-0430).
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Communication
Testing Nanomaterials of Unknown Toxicity: An Example Based on Platinum Nanoparticles of Different Shapes†
Article first published online: 17 OCT 2007
DOI: 10.1002/adma.200701962
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Advanced Materials
Special Issue: Special Section on Bionanotechnology
Volume 19, Issue 20, pages 3124–3129, October, 2007
Additional Information
How to Cite
Elder, A., Yang, H., Gwiazda, R., Teng, X., Thurston, S., He, H. and Oberdörster, G. (2007), Testing Nanomaterials of Unknown Toxicity: An Example Based on Platinum Nanoparticles of Different Shapes. Adv. Mater., 19: 3124–3129. doi: 10.1002/adma.200701962
- †
Publication History
- Issue published online: 17 OCT 2007
- Article first published online: 17 OCT 2007
- Manuscript Received: 7 AUG 2007
Funded by
- U.S. Environmental Protection Agency. Grant Number: RD-83172201-0
- Department of Defence. Grant Number: MURI FA9550-04-1-0430
- Abstract
- References
- Cited By
Keywords:
- Bionanotechnology;
- Cells;
- Inorganic nanoparticles;
- Platinum;
- Toxicity
Human endothelial and lung epithelial cells were exposed to nanosized Pt shapes following acellular analyses of their oxidant potential. Despite clear evidence of particle uptake by cells, the Pt nanoparticles were not found to induce cytotoxicity or oxidative stress in either cell type. Results from in vivo respiratory tract exposures suggest that the particles are retained by lung tissue and that minimal-mild lung inflammation results from exposure to the nanosized Pt particles.