The authors would like to thank Dr. Myron Spector of the Brigham and Women's Hospital for helpful discussions and donation of the primary osteoblasts. They would like to acknowledge Nicki Watson of the Whitehead Institute for her assistance with TEM. This work was sponsored by the Singapore-MIT Alliance. S.M. acknowledges the support of a National Science Foundation Graduate Research Fellowship. Supporting Information is available online from Wiley InterScience or from the authors.
Calcium-Doped Organosilicate Nanoparticles as Gene Delivery Vehicles for Bone Cells†
Article first published online: 17 OCT 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Special Section on Bionanotechnology
Volume 19, Issue 20, pages 3130–3135, October, 2007
How to Cite
Moudgil, S. and Ying, J. Y. (2007), Calcium-Doped Organosilicate Nanoparticles as Gene Delivery Vehicles for Bone Cells. Adv. Mater., 19: 3130–3135. doi: 10.1002/adma.200701969
- Issue published online: 17 OCT 2007
- Article first published online: 17 OCT 2007
- Manuscript Received: 3 AUG 2007
- Singapore-MIT Alliance
- Gene Delivery;
Calcium-doped organosilicate nanoparticles for gene delivery are prepared by using a surfactant-mediated sol-gel synthesis. The enhanced uptake of these nanoparticles by osteoblast cells (see figure) makes them promising candidates for the transfection of bone cells. The complexes of Ca-SiO2 nanoparticles with DNA transfect bone cells effectively without inducing cytotoxicity in vitro.