Intracellular Enzymatic Formation of Nanofibers Results in Hydrogelation and Regulated Cell Death


  • This work was partially supported by RGC (Hong Kong), EHIA (HKUST). Supporting Information is available online from Wiley InterScience or from the authors.


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Enzymatic formation of supramolecular nanofibers is demonstrated as a novel approach to induce intracellular hydrogelation and control the fate of cells or cellular functions, which can lead to a new paradigm for developing biomaterials to manage cellular artificial nanostructures (CAN), understand cellular functions beyond the molecular level, and create novel therapeutics.