This work was supported by the National Institutes of Health (EB-001777), the National Science Foundation (CHE-0243496), and a grant from the Oncological Sciences Center at Purdue University. The authors thank Hongtao Chen for his assistance in SPT analysis, Professor Philip Low for providing folate-Bodipy and KB cells, and Professor Stephen Konieczny for providing NIH-3T3 cells. Supporting Information is available online from Wiley InterScience or from the authors.
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Communication
Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity†
Article first published online: 17 OCT 2007
DOI: 10.1002/adma.200701974
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Advanced Materials
Special Issue: Special Section on Bionanotechnology
Volume 19, Issue 20, pages 3136–3141, October, 2007
Additional Information
How to Cite
Tong, L., Zhao, Y., Huff, T., Hansen, M., Wei, A. and Cheng, J.-X. (2007), Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity. Advanced Materials, 19: 3136–3141. doi: 10.1002/adma.200701974
- †
Publication History
- Issue published online: 17 OCT 2007
- Article first published online: 17 OCT 2007
- Manuscript Received: 3 AUG 2007
Funded by
- National Institutes of Health. Grant Number: EB-001777
- National Science Foundation. Grant Number: CHE-0243496
- Oncological Sciences Center at Purdue University
Keywords:
- Biomedical materials;
- Bionanotechnology;
- Inorganic nanorods;
- Luminescence;
- Membranes
Graphical Abstract
Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.