Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity


  • This work was supported by the National Institutes of Health (EB-001777), the National Science Foundation (CHE-0243496), and a grant from the Oncological Sciences Center at Purdue University. The authors thank Hongtao Chen for his assistance in SPT analysis, Professor Philip Low for providing folate-Bodipy and KB cells, and Professor Stephen Konieczny for providing NIH-3T3 cells. Supporting Information is available online from Wiley InterScience or from the authors.


original image

Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.