In Situ Molecular Profiling of Breast Cancer Biomarkers with Multicolor Quantum Dots


  • This work is supported by the Emory-Georgia Tech CCNE consortium, Georgia Cancer Coalition (S.N. and R.M.O.R GCC Distinguished Scholars), and NSF (X.H.G. NSF-CAREER award). We are also grateful to Prof. Larry True (UW Pathology) for fruitful discussion.


original image

Quantum dot bioconjugates can be used for multiplexed and quantitative detection of tumor biomarkers in cells and tissues. This new technology should have significant impact on molecular pathology if validated with traditional techniques (such as western blotting, FISH, and IHC), and with large-scale clinical studies. In addition, it could also become the first clinical application of quantum dots.